Innovation Consulting: Patent Office, Industrial Inventions, European patent applications - Rome, Milan.


Legal Representative in front of the European Patent Office

Legal Representative in front of the Euipo


Studio Zizzari can assist you with European Regional Phase Entry, direct filings, or legal counsel and assistance with any pending European applications.

We are Legal Representatives in front of the European Patent Office (EPO n. 09003820).

We understand that the most important qualities you are looking for in a EU associate are reliability, prompt service, and competitive pricing. It is also our goal to give you clear and straightforward flat fee prices.

Please notify Studio Zizzari at least one month in advance of the 31-month PCT deadline.

In order to contact us, please send an email to:


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11 july 2017 - The present invention regards a medical device that is represented by a temporary venous transfemoral or trans-saphena endoprosthesis for a total vascular exclusion of the liver.
This device results to be particularly adapt to be used in most critical surgical operations involving this organ, like in example in major hepatectomy and in hepatic trauma with caval upper hepatic venous damage.

In fact, the endoprosthesis represents an internal and temporary endovenous bypass that permits the normal function of the caval vein to return the blood to heart, and at the same time permits, with a simultaneous Pringle maneuver, the total vascular exclusion of the hepatic parenchyma.

The liver receives blood coming from the portal vein and from the hepatic vein, and returns filtered blood to the caval system through the three upper hepatic veins. The vascular exclusion of the liver, according to the invention, consists in stopping the blood entering the liver, by blocking the hepatic peduncle (hepatic artery, common bile duct and portal vein) with a clamp or a tourniquet, and stopping simultaneously the way out, in such a way that the blood cannot enter the liver from the inferior caval vein through the upper hepatic veins.

Therefore, it is used the Pringle maneuver, that is well known from the current surgical techniques, in order to stop the way of the blood to the liver, and it is blocked the way out of the liver closing the upper hepatic veins, by intervention directly on the caval vein, from the inside. This blocking of the way out is achieved by installation of an endoprosthesis, that is inserted directly from the femoral vein or saphena and then it is pushed inside the inferior caval vein, reaching with the distal part the caval lower and upper hepatic tract, blocking therefore with the lateral walls the holes connecting the upper hepatic veins to the caval vein.

The endoprosthesis is composed of a main part having a cylindrical shape extending longitudinally. The part that, once it has been pushed in the caval vein, is placed close to the distal part of a inner guide, opens a spiral shaped self-expandable thin sheet, in order to bond steadily to the inside wall of the caval vein. The expansion saves an inner caval space that is necessary to keep the flow of blood inside, so that the function of blood return to heart is saved.

Studio Zizzari has prepared and filed the European patent application and achieved a full positive opinion by the examiners in order to release the patent.

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6 july 2018 - The invention regards a device for medical use comprising an injector without needle, said device being used to apply a desensitization and/or immunostimulant or any other type of medicine therapy to an underskin tissue. The injector without needle includes an electronic and mechanic control system monitoring the cutaneous tissue to which the same device is applied.

As known, in the state of the art injector devices without needle are widely used, and they are used especially to overcome the drawbacks of the syringe with needle.
In fact, the penetration of skin with a needle is not without risk, especially in case that the person providing the injection is not an expert. The side effects, in the person receiving the injection, can be of different type, like in example: pain, hematoma, formation of scar tissue, infection or abscess, transmission of infective diseases (in case the used needles are not of the single use type).

One of the known systems is that called Penjet®, that works in a simple way, using a mechanism of air pressure and belongs to the class of prefilled syringes without needle, for liquid and lyophilized medicines.
Another of the known systems is that called Injex®, that ejects a thin high pressure jet of liquid going through the surface layers of skin. The pressure is generated by the energy of a spring, and it is sufficient to make the medicine to pass through reaching a depth that is comparable to that reached by a standard needle, providing therefore a good level of absorption.
Another further of the known systems is that called PowderJect®. It is an injection device powered by a micro-cylinder filled of gas, and uses a small container in order to supply a powder of medicine in the jet of gas. The medicine should be composed of dry particles having a specific granularity and size.

All the above systems of the prior art have some significant drawbacks, that are critical at the time when an injector without needle is used to make an injection in the underskin tissue. Two very critical aspects for this type of operations are the following: the correct adherence on pressure of the device end to the cutaneous tissue where it is applied; the correct placement of the device on the proper tissue for the specific type of injection and used medicine.

Therefore, it is specific objective of the present invention to propose a device for medical use, comprising an injector without needle, said device being able to inject a medicine or another substance to an underskin tissue of a patient.
The injector device includes an electronic and mechanic control system able to detect the exact value of pressure at the end of the device, placed on the cutaneous tissue where it is applied, and the type of the same tissue, for example of muscular type or adipose type.

Studio Zizzari has prepared and filed the international PCT application making reference to all the States of the world.

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31 may 2018 - The present invention concerns a medical device, particularly suitable for protection and non-traumatic support of a surgical cavity, inside the body of a patient that is submitted to a surgical operation, in order to achieve an inner protected space where surgical instruments can be inserted.

As known, the current techniques of surgery include the use of specific instruments, so called retractors, in order to achieve and keep a space inside the body of a patient. These retractors are of different types and, usually, are composed of some real metallic pincers, that are attached at their distal end to an anatomical tissue of the same patient, in example to the edge of a skin layer, and at the other end to an outer structure or to a stiff frame. More of these retractors can be used in great operations, in order to keep an open and stable cavity and permit the insertion and the handling of surgical instruments inside the body of a patient.

All the above retractors imply the serious drawback of keeping the anatomical tissues of the same patient, at points of attachment, under hard stretching, all during the time of operation. This fact cannot avoid to generate traumas and/or local injuries that, although are quickly recovered during the stay in the hospital, can cause pain and/or possible after-surgery complications for the patient.

Therefore, the present invention arises from the need to find some alternative ways to achieve an inner surgical space inside the body of a patient, that is stable and permits the insertion and handling of surgical instruments and decreases, at the same time, the possibility of direct or indirect damages to the patient. In fact, besides the above said injuries at the attaching points of retractors, some incidental traumas are possible, in example due to a sudden and unexpected motion of instruments and/or anatomical parts of the patient, and other traumas due to an operation in emergency conditions with low visibility, where in example it happens to have inner hemorrhage and/or diffusion of inner biological liquids that are not drained promptly.

Therefore, the main objective of the present invention is to disclose a specific medical device, for protection and non-traumatic support of a surgical cavity, that can be easily inserted in the body of a patient, and that can be adapted smoothly so that it can express a gradual and homogeneous pressure towards the tissues of the same patient, all along the outline of the contact wall.
Another objective is that the same device can be adapted, and the stiffness of the walls can be increased, on command, by inserting air in proper airtight chambers, contained inside the same contact walls.
Another further objective is that the same device includes some specific accessories, like in example: some spatulas (with respective housings) and some hooks suitable for a stable positioning of the same device inside the patient; some suction/drainage means so that the surgical space is kept free of possible operative and/or biological liquids, that can be lost; and means of lighting, so that the surgical space is kept enlightened and it is possible a direct vision of the area of intervention.

Studio Zizzari has prepared and filed the European patent application and achieved a full positive opinion by the examiners in order to release the patent.

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18 january 2018 - The present invention regards a device that can be properly used for training of golf players, and more in particular in order to train the swing, that is a specific movement that is achieved when the ball is hit and launched towards a target, making the same ball to lift up from ground.

As known, in order to practice the swing, the player puts his body in front of the ball, he takes the club using both his hands, and brings the club behind his head, making his shoulders and back to rotate. From a position having the club on the top, he starts the way down to the ball, by a rotary motion towards the objective of reaching and hit the ball. At the time of contact with the ball, the motion of the hip and the rest of the body continues. When the club and the arms point to the target, the head starts to turn. At the time that the ball has been hit and launched in the air, the last step of the swing starts: the hip completes the rotation, the arms move in angle and the body results to be directed to the target, with the club touching the back behind the neck.

Therefore, the main objective of the present invention is to propose a device for training the swing, addressed to golf players, giving the support of a fixed point to the head, so that the player can become comfortable with the movements, rotating the bust and keeping the head fixed until the time of the contact with the ball has reached.

The system is able to detect the angle of rotation of the player's bust in respect to the front direction, and able to provide a start signal for the execution of the swing, by an acoustic or visual signal, or by a graphic message on a video screen.

The system is able to detect the dynamics of the club's motion and, at the moment of touch with the ball, to detect the exact position of the club's end, the player's head and feet, so that it can be recognized if the swing has been executed correctly or not.

The system of the invention can be integrated in more complex systems for simulation of the golf game that use the computer graphics projected on maxi-screens, in order to reconstruct some virtual fields of golf, and that the device uses the data detected in the swing in order to define the drive, direction, speed and effect given to the ball.

Studio Zizzari has prepared and filed the European patent application and achieved a full positive opinion by the examiners in order to release the patent.

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23 october 2017 - The present invention relates to a multilayer flexible element, preferably made of wood, and related production process by laser engraving and/or cutting. More exactly, the production process consists in the processing of materials, in which a material previously rigid after the processing acquires characteristics and properties typical of a tissue, in such a way to be suitable as raw material, preferably in clothing, furnishing and design. The production process is based on the use of a laser device able to realize a pattern of grooves on the top layer of a multilayer material that, after the processing, can be used in the same way as a flexible material.

In the state of the art procedures have already been developed to make products made of wood or other rigid material appropriately worked to create a flexible structure that can adapt to various shapes and profiles, so that the above-mentioned products can be used as clothing accessories or furnishing. In some cases, these structures are real clothes. The technique used up to now consists in realizing a basic structure articulated, for example a metallic structure with some pins that allow the rotation of a part on the other, within this metallic structure are inserted wooden dowels to form a mosaic. The procedure provides for the cut of the single dowels, and the subsequent manual installation, one at a time, up to form the final product. This processing determines a problem of precision, for the fact that intervenes an operator to realize the product, and there is also a problem of timing, because the processing must follow a manual operation. There is also a problem of costs because to realize a single product you employ a certain quantity of raw material, a certain time to design the product and manufacture it manually, and also you need labor which must intervene directly.

All the above disadvantages are overcome by the present invention which has as main objective to make usable the same way of a tissue or other flexible material, those materials (preferably wood, but also laminates, aluminum, etc..) which by their nature and characteristics have a rigid structure and limited modeling.

A further objective is that such materials, adequately processed, can be used in the applications already in use both for tissues that for the leather.

Another objective is to use these materials (wood, laminates, plexiglas, aluminum, copper, etc..) in order to enrich the range of materials already usable in clothing and design, particularly in textiles and tanneries.

A further objective is that the mode of processing ensures high speed and precision. Another objective is that this processing technique is extremely versatile in such a way you can operate in different sectors, from clothing to furnishings, up to the automotive industry.

A further objective is that this processing is without direct contact with the material, so as to provide the maximum safety for the operator. Another objective is that the laser engraving and/or cutting should be permanent, unalterable and unchangeable.

Studio Zizzari has prepared and filed either the Italian patent application and the International PCT application, achieving a full positive opinion by the examiners in order to release the respective patents. The patents have been obtained as European Patent, in China, Japan, Canada and Russia.

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30 august 2017 - The present invention relates to an improved device for conversion of mechanical energy from sea waves to electric energy, that includes a float moved by sea waves, where the resulting displacement of the same float is given by the superposition of the horizontal (sway), vertical (heave) and rotational (roll) displacements, and that transmits some wave actions to some rigid rods, or to some cables, that are anchored through hinges to the sea bed. The rods are connected to respective ballasts and to a transmission shaft of an electric generator, by using cables or chains. The rotary oscillating motion of the rods is used to put the transmission shaft of the electric generator.

The main objective of the present invention is to propose an improvement in the device for conversion of mechanical energy from sea waves to electric energy disclosed in the Italian patent IT 1413116, by introducing an improvement in the connection structure of float cables, and in the position of generator transmission gears. The float connection structure and a different position of generator allow to increase the roll of the float (the rotary motion with reference to its center of mass), in respect to the heave (vertical) and to the sway (horizontal) oscillations, increasing the general efficiency of the total extracted energy in the device.

The position of the transmission shaft and the position of the generator is better, from an economical point of view, due to three reasons. The first is that the number of mechanical transmission gears and generators is decreased, and therefore a decrease of costs in construction and maintainance are achieved. The second is that the mechanical stress in the structure is decreased, and it is not of bending type but it is of axial type, more exacly of traction type, therefore cheaper rods can be used, or they can be changed with cables or ropes that are significantly cheaper than rods. The third is that it is possible to achieve a rotational speed in the generator transmission shaft that is higher in respect to that having a configuration where the generator is placed at the hinges; that achieves a simpler, cheaper and more efficient multiplier of revolutions per minute, that are necessary to make the electrical generator to work properly.

Another objective is that the same device has a stable equilibrium point, and that the horizontal or vertical or rotational oscillations in respect to the same point make it possible to activate an electrical generator.
Another further objective is that the same device should be installed off-shore in respect to deep water or to shallow water.
A furter objective is that the same device should be part of a modular system that permits to produce a quantity of energy that is proportional to the amount of used sea surface, and proportional to the number of installed modules.
Another further objective is that, when the main direction of sea waves changes, the same device should adapt its orientation automatically without installing any additional add-ons.

Studio Zizzari has prepared and filed either the Italian patent application IT 10 2015 000041327 and the International PCT application PCT/EP2016/068591, achieving a full positive opinion by the examiners in order to release the respective patents.

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22 august 2017 - The present invention is related essentially to a surgical system including a catheter with balloon and needle, some guiding wires and a vascular stent properly shaped. The system permits to achieve, working through endovascular ways only, a by-pass connecting vascular segments that are not functionally contiguous. In such a way the blood can overcome an obstruction that is occurred inside a blood vessel.

As known, the aortocoronary by-pass has always been considered a solution in the treatment of the three-vessels coronary diseases (that is when all the three coronary branches are involved), either in case of serious or mild diseases. That happens although in recent years the stents technology, and especially the drug eluting stents technology, has increased significantly the safety and the effectiveness of these devices in the treatment of the atherosclerotic coronary disease. With reference to that, also the most recent clinic trials that compare the two techniques of revascularization have demonstrated as the aortocoronary by-pass results to be significantly better, with reference either to decrease of mortality and to decrease of the risk of heart attack, yet after five years since the treatment with increase of the benefit according to the passing of time.

It is widely demonstrated that, the significant advantage of the traditional surgery, in respect to the endovascular techniques, arises especially from the use of the internal mammary artery (IMA) as the vessel chosen for the revascularization of the left anterior descending artery (LAD). Indeed, the IMA presents a low risk of obstruction and atherosclerosis due to the local characteristics keeping an open flow in the long term, even compared to the vessel grafts (SVG). That achieves a good flow of oxygenated blood in the area of distribution of the anterior descending artery (LAD), with significant perfusion pressures, even in case of serious disease in the receiving vessel. It is commonly observed that, in case of very serious events of atherosclerotic burden, the levels of coronary reserve are significantly higher when an arterious graft is installed in the internal mammary artery.

Recently, a trial using computed tomography to detect the anatomic shapes of the thoracic vascular structures has permitted to evaluate how the left internal mammary artery (LIMA) is very close to the anterior descending artery (LDA). Indeed, in all the analyzed patients there is a point in the chest where the two arteries cross by, being separated by just few millimeters of serous tissue. Furthermore, since the beginning of the past century it is well know the presence of natural by-passes connecting the internal mammary artery to the coronary artery through the pericardiacophrenic branch. The presence of these anastomosis has been indeed the rational of the surgical connection of the IMA before the introduction of the aortocoronary by-pass. Recently, a research has shown that in large part of patients it is possible to recruit functioning connections between the left internal mammary artery (LIMA) and the LAD, and between the right internal mammary artery (RIMA) and the right coronary (RC).

The proposed method, disclosed by the present invention, permits to achieve a by-pass between the left internal mammary artery (LIMA) and the LAD, and between the right internal mammary artery (RIMA) and the right coronary (RC), using a technique that is exclusively endoscopic, taking advantage of the close distance of the two respective vascular structures. The same technique can be used in order to achieve other by-passes in other vascular segments either.

The present endovascular technique permits the revascularization with the internal mammary artery even in persons that are now excluded from the traditional surgery, and opens new opportunities to the endovascular surgery. That decreases the postsurgery complications and does not require the deep sedation and the orotracheal intubation of the patient. It further permits a very fast recovery from the surgery, without the requirement to monitor the patient in a post-surgery intensive care unit. The absence of a deep anaesthesia further increases the number of treatable patients: big obese persons, patients affected by chronic respiratory failure or degenerative diseases like Alzheimer, or very old persons.

Studio Zizzari has prepared and filed the European patent application EP 17425073.

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